ERp29

ERp29 är ett protein i det endoplasmatiska retiklets lumen. Det är ett chaperon, som hos människor kodas av ERP29 -genen,^[1] alltså ett protein som hjälper andra proteiner att veckas.

Funktion

ERp29 visar sekvenslikhet med proteindisulfid-isomerasfamiljen.^[2] Emellertid saknar det tioredoxinmotivet som är karakteristiskt för denna familj, vilket tyder på att proteinet inte fungerar som ett disulfidisomeras.^[2] Proteinet dimeriserar och tros spela en roll i bearbetningen av sekretoriska proteiner inom ER. Alternativ splitsning resulterar i flera transkriptvarianter som kodar för olika isoformer.^[1]

Referenser

Den här artikeln är helt eller delvis baserad på material från engelskspråkiga Wikipedia, ERP29, 4 mars 2023.

Noter

^ [a b] ”Entrez Gene: ERP29 endoplasmic reticulum protein 29”. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10961.
^ [a b] ”The human protein disulfide isomerase gene family”. Human Genomics 6 (1): sid. 6. July 2012. doi:10.1186/1479-7364-6-6. PMID 23245351.

Vidare läsning

”Functional proteomics: The goalposts are moving”. Proteomics 2 (9): sid. 1069–78. Sep 2002. doi:10.1002/1615-9861(200209)2:9<1069::AID-PROT1069>3.0.CO;2-R. PMID 12362325.
”ERp29, an unusual redox-inactive member of the thioredoxin family”. Antioxidants & Redox Signaling 8 (3–4): sid. 325–37. 2006. doi:10.1089/ars.2006.8.325. PMID 16677078.
”Human liver protein map: a reference database established by microsequencing and gel comparison”. Electrophoresis 13 (12): sid. 992–1001. Dec 1992. doi:10.1002/elps.11501301201. PMID 1286669.
”Human liver protein map: update 1993”. Electrophoresis 14 (11): sid. 1216–22. Nov 1993. doi:10.1002/elps.11501401181. PMID 8313870.
”A stress-inducible rat liver endoplasmic reticulum protein, ERp29”. European Journal of Biochemistry 251 (1–2): sid. 304–13. Jan 1998. doi:10.1046/j.1432-1327.1998.2510304.x. PMID 9492298.
”ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif”. European Journal of Biochemistry 255 (3): sid. 570–9. Aug 1998. doi:10.1046/j.1432-1327.1998.2550570.x. PMID 9738895.
”Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping”. Electrophoresis 21 (17): sid. 3785–96. Nov 2000. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497.
”ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production”. The Journal of Histochemistry and Cytochemistry 50 (4): sid. 557–66. Apr 2002. doi:10.1177/002215540205000413. PMID 11897809.
”Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29”. Gene 285 (1–2): sid. 127–39. Feb 2002. doi:10.1016/S0378-1119(02)00417-1. PMID 12039039.
”Proteomic analysis of early melanosomes: identification of novel melanosomal proteins”. Journal of Proteome Research 2 (1): sid. 69–79. 2003. doi:10.1021/pr025562r. PMID 12643545.
”A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell 125 (4): sid. 801–14. May 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
”Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma”. The American Journal of Dermatopathology 28 (5): sid. 410–2. Oct 2006. doi:10.1097/01.dad.0000211521.49810.ac. PMID 17012915.
”Purification and structural characterization of human ERp29”. Protein and Peptide Letters 13 (8): sid. 753–9. 2006. doi:10.2174/092986606777841190. PMID 17073718.
”Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes”. Journal of Proteome Research 5 (11): sid. 3135–44. Nov 2006. doi:10.1021/pr060363j. PMID 17081065.
”Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones”. The Journal of Biological Chemistry 282 (15): sid. 11213–20. Apr 2007. doi:10.1074/jbc.M604440200. PMID 17296603. http://pubman.mpdl.mpg.de/pubman/item/escidoc:595754/component/escidoc:595753/332702.pdf.

Externa länkar

[entrez-1] [a b] ”Entrez Gene: ERP29 endoplasmic reticulum protein 29”. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10961.

[humgenomics.com-2] [a b] ”The human protein disulfide isomerase gene family”. Human Genomics 6 (1): sid. 6. July 2012. doi:10.1186/1479-7364-6-6. PMID 23245351.

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